Impact and Benefits
Penta Series is engineered to reverse the process of aging and brings exuberance of youth back to your skin. Incorporating our patented technology, Penta ™ EBN Hydrolysate, together with phyto-extracts and Arginine Peptide that provide synergistics effects, gradual usage will see positive beneficial results in reducing fine lines and wrinkles. Different kinds of plant extracts are added to achieve optimum skin brightening and anti-oxidant effect.
The research works carried out also indicated the presence of epidermal growth factor (EGF)-like substance in EBN, has drawn the attention of consumers as well as researchers. Since then, extensive research activities have been conducted to confirm the presence of EGF-like substance in EBN and its potential use in medical field and cosmetic industry for cell proliferative effect. According to a scientific research, epidermal growth factor (EGF)-like activity was detected in bird nest. However, raw unprocessed bird nest will not be able to exhibit EGF effect. Whereas after process, the partially purified EGF-like activity was able to stimulates cell growth and improve overall skin conditions. Salivary EGF, such as protein identified in EBN has been reported to possess fibroblast growth-promoting activity. It is conjectured to be a key factor of its nourishing and/ or medicinal functions where it can stimulated cell division and growth as well as enhanced tissue growth and regeneration.
So, what is EGF and how does it benefits to us?
Epidermal growth factor (EGF) is a small polypeptide that has been successfully identified in processed edible bird nest.
Epidermal growth factor (EGF) consists of a family of peptides, of which EGF and transforming growth factors alpha (TGF-α) are two of the most studied members. These growth factors can enhance mucosal healing after injury by increasing cell proliferation and stimulating angiogenesis. Epidermal Growth Factor increases cell renewal after any exfoliation and assists the skin in wound healing. It is an excellent maintenance as it nourishes and provides support that slows down the aging of the skin. By providing the skin with this essential nutrient, the skin will become healthier.
Epidermal Growth Factor (EGF) plays important role in the process of wound healing. Proliferation and migration of epithelial cells plays critical role in wound healing, EGF is a known factor in promoting fibroblast proliferation and epithelial cells migration, thus promote wound healing.
The effect of EBN Hydrolysate on wound healing was examined by scratch test. Normal human keratinocytes was cultured in petri dish. Damage model was induced by scratching a line in the centre of the dish. Wound healing at scratched area was observed after 24-hour (Experimental Protocol of Scratch Test). As presented in Figure 2.6 (The Effect of EBN Hydrolysate on Wound Healing), accelerated wound healing effect was observed in dish treated with EBN Hydrolysate, the effect is dose-dependent. Thus, it is suggestive that EBN Hydrolysate promotes wound healing.
Tight junctions (TJ) refer to closely associated area of two adjacent cells whose membrane join together forming a virtually impermeable barrier to fluid. In the epidermis, TJ plays crucial role in the formation and maintenance of epithelial barriers prevent invasion of foreign particles. In the stratum corneum, ceramide acts as first line of skin barrier function. TJ in the stratum granulosum acts as second line of skin barrier function. They forms important barrier that protects from external organism, preventing excessive water loss and selectively transport of small solutes through the skin.
From all the studies above, Penta Series has been proven with all the benefits towards aging skin, including skin cell proliferation, wound healing and skin tightening. The main components are from the sialic acid and epidermal growth factor (EGF).